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Vol. 15. Issue 4.
Pages 187-195 (October - December 1979)
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Vol. 15. Issue 4.
Pages 187-195 (October - December 1979)
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Transporte de oxigeno
Transportation of oxygen
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María Teresa García Carmona*
* Jefe Adjunto del Servicio de Funciones Respiratorias. Clínica Puerta de Hierro. Centro Nacional de Investigaciones medico-quirúrgicas de La Seguridad Social. Madrid
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Se hace una revisión general den transporte de oxígeno orientado principalmente el análisis de los aspectos bioquímicos implicados en él, comenzando por estudiar el papel de la hemoglobina como transportadora de oxígeno, tanto en lo que se refiere a su concentración como a su afinidad por el oxígeno.

Se estudia el significado de la máxima capacidad de oxigenación destacando la importancia que puede tener la presencia de caboxihemoglobina en la sangre, ya que ésta disminuye el valor teórico de la mencionada máxima capacidad de oxigenación. Se propone una corrección para el cálculo en el laboratorio del oxígeno que transporta una sangre, teniendo en cuenta la concentración de carboxihemoglobina, siempre que se trate de personas fumadoras o se presuma que existan concentraciones elevadas de la misma.

A continuación se hace un estudio profundo de la afinidad de la hemoglobina por el oxígeno a través de la curva de disociación, comenzando por definir la P50 y discutiendo el significado fisiológico de los desplazamientos de dicha curva como consecuencia de los cambios de afinidad. Se describen en detalle la estructura de la molécula de hemoglobina, así como los fenómenos que se producen durante la oxigenación y desoxigenación del tetrámero de hemoglobina. Se incluyen también los mecanismos de regulación de la afinidad de la hemoglobina por el oxígeno, resaltando la importancia de los hidro-geniones, PCO2 y concentración de 2,3 DPG en esta regulación, siendo los aumentos de acidez y PCO2 mecanismos de acción rápida, mientras que los de 2,3 DPG tardan algunas horas en producirse.

Se exponen brevemente los métodos de medida y se analizan las modificaciones de la afinidad de la hemoglobina por el oxígeno en diversas situaciones fisiológicas y patológicas.

Se describen los mecanismos de consumo de oxígeno a nivel celular, la formación de ATP y la utilización de la energía almacenada en esta molécula por el organismo. Por último, se expone la producción de ATP en casos de anaerobiosis por medio de la glucólisis anaerobia, destacando que es necesaria la producción de una considerable cantidad de ácido láctico para satisfacer las necesidades energéticas por esta vía. Se mencionan las limitaciones que supone el empleo del aumento de la relación L/P y el exceso de lactato para diagnosticar las hipoxias celulares.

Summary

The authors make a general review of the transportation of oxygen oriented principally towards the analysis of the biochemical aspect implied in this process. They begin by studying the role of hemoglobin as transportation agent of oxygen, both with respect to ist concentration as wel as to its affinity for oxygen.

They also study the meaning of the maximum capacity of oxygenation, emphasizing the importance that carboxyhemoglobin in the blood can have, as this decreases the theoretical value of the mentioned maximum capacity of oxygenation. They propose a correction for the calculation in the laboratory of the oxygen transported by the blood taking into account the concentration of carboxyhemoglogin, always when the persons treated are smokers or they presume an elevated concentration of the same.

The authors then make a profound study of the affinity of hemoglobin for oxygen through the curve of dissociation, beginning by defining P30 and discussing the physiological meaning of the displacement of said curve as a consequence of the changes of affinity. They describe in detail the structure of the molecule of hemoglobin as well as the phenomena produced during the oxygenation and desoxygenation of the tetramer of hemoglobin. They also include the mechanisms of regulation fo affinity of hemoglobin for oxygen, emphasizing the importance of hydrogen ions, PCO2 and concentration of 2,3 DPG in this regulation. The increases of acidity and of PCO2 are mechanisms of rapid action, whereas those of 2,3 DPG delay some hours in being produced.

The authors then describe birefly the methods of measurement and analyze the modifications of the affinity of hemoglobin for oxygen in diverse physiological and pathological situations.

They also describe the mechanisms of concumption of oxygen at the cellular level, the formation of ATP and the use of energy stored in this molecule by the organism. Finally, they discuss the production of ATP in cases of anaerobiosis by means of glycolysisanaerobia, emphasizing that the production of a considerable quantity of lactic acid is necessary to satisfy energetic necessities by this route. They mention the limitations that the use of the increase of the relation L/P supposes and the excess of láclate for diagnozing cellular hypoxias.

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Copyright © 1979. Sociedad Española de Neumología y Cirugía Torácica
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