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Vol. 13. Issue 3.
Pages 168-173 (July - September 1977)
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Vol. 13. Issue 3.
Pages 168-173 (July - September 1977)
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Estudio de las alteraciones de las propiedades tensioactivas del surfactante pulmonar del perro por la produccion de un enfisema experimental papainico
Study of the alterations of the tensioactive properties of the pulmonary surfactant in dog, by the production of a papainic emphysema
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B. Vicens, J. Reventós, E. Concustell
Servicio de Asmatología y Alergia Servicio de Cirugía Experimental, Servicio de Bioquímica, Hospital de la Santa Cruz y San Pablo. Barcelona
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En el presente trabajo se han estudiado las propiedades tensioactivas y la composición bioquímica del surfactante pulmonar obtenido por lavado en nueve perros bastardos antes y después de haberles provocado un enfisema panlobulillar experimental mediante papaína, para tratar de establecer un nexo de unión entre dos teorías etiopatogénicas invocadas para el enfisema, por un lado la disminución de la tensión superficial del surfactante pulmonar, y por otro la digestión proteica intrapulmonar anormal secundaria a una disminución de la inhibición de las proteasas liberadas en el pulmón por diferentes mecanismos. Los resultados sugieren que en la génesis del enfisema podrían jugar un papel tanto el aumento de la proteolisis intrapulmonar como la alteración de la actividad tensioactiva del surfactante pulmonar, probablemente dependiendo el segundo hecho del primero, si bien de forma diferente a la que inducían a pensar los estudios realizados hasta la fecha.

Summary

The tensoactive properties as well as the Biochemical composition of the pulmonary surfactant obtained by washlung in nine mongrel dogs, before and after papain-induced panlobulillar experimental emphysema was obtained, are studied. A relationship between the two advocated theories for the production of emphysema is tried to establish: a) The diminution of surface tension of pulmonary surfactant and b) The abnormal intrapulmonary proteic digestion secundary to a diminution of the inhibition of the proteases liberated by the lung by various mechanisms. The results suggest that in the genesis of emphysema the increase of the intrapulmonary proteolysis, as well as the alteration of the tensoactivity of the surfactant could play an important role. Possibly the latter fact is secondary to the former one, but in a different way as it is considered at present.

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Este trabajo ha sido realizado gracias a la ayuda de las Fundaciones María Francisca Roviralta y Picasso-Reventós de Barcelona.

Copyright © 1977. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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