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Vol. 28. Issue 7.
Pages 341-347 (October 1992)
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Vol. 28. Issue 7.
Pages 341-347 (October 1992)
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Dobles neoplasias de pulmón y laringe
Double neoplasm of lung and larynx
Visits
3460
J. Moya
Servicios de Cirugía Torácica.Hospital Bellvitge. Hospitalet. Barcelona
A. Arellano*
* Servicios de Oncología Radioterápica. Hospital Bellvitge. Hospitalet. Barcelona
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En las últimas décadas se ha experimentado un aumento progresivo de dobles neoplasias primarias del tracto aerodigestivo, concretamente de las dobles neoplasias pulmonares primarias (DNPP) y dobles neoplasias primarias de laringe y pulmón. Tras realizar una revisión bibliográfica actualizada sobre el tema, se aporta la experiencia de los autores en tres casos de DNPP y 11 casos de DNP laringe-pulmón, atendidas durante un período de 18 años.

En los casos de DNPP, el 66% de los pacientes estaban en estadio I y el 34% en estadio II. Todos los casos de primera neoplasia pulmonar primaria (PNPP) eran escamosos con grado de diferenciación G1 en el 66% y G2 en el 34%; así mismo la presentación de la segunda neoplasia primaria (SNP) fue metacrónica en el 66% y sincrónica en el 34%.

Cuando las DNP eran de laringe-pulmón se observó una afectación laríngea en el 81% de las PNP; todos los casos fueron escamosos en su primera presentación con un grado G1 en el 72%, perteneciendo al estadio I un 80% y al II un 20%; las presentaciones metacrónicas llegaron al 63% y las sincrónicas al 37%.

La supervivencia global (desde la PNP) es 1,3 veces mayor que la supervivencia siguiente a la SNP, cuando se trató de DNPP; mientras que en las DNP laringe-pulmón, la supervivencia global es 2,7 veces mayor que la siguiente a la SNP.

During the last decades, the incidence of double primary neoplasms (DPN) of the digestive tract has progressively increased, specially the incidence of DPN of the lung and DPN of the larynx and lung. This study reports a bibliographic revision of the literature and the clinical experience of the authors based in three cases of DPN of the lung and 11 cases of DPN of the lung and larynx observed during a period of 18 years. Patients with DPN of the lung were at stage I in 66% of instances and at stage II in the remaining 34%. All cases of first primary pulmonary neoplasm were of the squamuous cell type with a differentiation degree G1 in 66% of cases and G2 in 34%. The presentation of the second primary neoplasm was metachronous in 66% and synchronous in 34%. In patients with DPN of the lung and larynx, laryngeal involvement in cases of primary pulmonary neoplasms was 81%. At the first presentation, all cases were of the squamous type with a differentiation degree G1 in 72%, stage I in 80%, stage II in 20%, metachronous presentation in 63%, and synchronous presentation in 37%. In cases of DPN of the lung the overall survival (since the occurrence of the first pulmonary neoplasm) was 1.3 times higher than the survival after the second neoplasm, whereas in cases of DPN of lung and larynx, the overall survival was 2.7 times higher than that following the second neoplasm.

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Bibliografía
[1.]
H. Beyreuther.
Multiplicität von Karzinomen bei einem Fall von sog. Schenneberger. Lungenkrebs mit Tuberkulose.
Virchows Arch Path Anat, 250 (1924), pp. 230-243
[2.]
W.B. Neptune, F.M. Woods, R.H. Overholt.
Reoperation for bronchogenic carcinoma.
Surg, 52 (1966), pp. 342-350
[3.]
O. Auerbach, A.P. Stout, E.C. Hammond, L. Garfinkel.
Multiple primary bronchial carcinomas.
Cancer, 20 (1966), pp. 699-705
[4.]
S.M. Lippman, W.K. Hong.
Second malignant tumors in head and neck squamous cell carcinoma: The overshadowing threat for patients with early-stage disease.
Int J Radiation Oncology Biol Phys, 17 (1989), pp. 691-694
[5.]
J.S. Cooper, T.F. Pajak, P. Rubin, et al.
Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience.
Int J Radiation Oncology Biol Phys, 17 (1989), pp. 449-456
[6.]
D.J.H. Wagenfeld, A.R. Harwood, D.P. Bryce, A.W. van Nostrand, G. De Boer.
Second primary respiratory tract malignancies in glottic carcinoma.
Cancer, 46 (1980), pp. 1883-1886
[7.]
D.J.H. Wagenfeld, A.R. Harwood, D.P. Bryce, A.W. van Nostrand, G. De Boer.
Second primary respiratory tract malignant neoplasms in supraglottic carcinoma.
Arch Otol, 107 (1981), pp. 135-137
[8.]
J.T.V. Licciardello, M.R. Spitz, W.K. Hong.
Multiple primary cancer in patients with cancer of the head and neck: second cancer of the head and neck, esophagus, and lung.
Int J Radiation Oncology Biol Phys, 17 (1989), pp. 467-476
[9.]
J.W. Berg, D. Schottenfeld, F. Ritter.
Incidence of multiple primary cancers III. Cancers of the respiratory and upper digestive system as multiple primary cancers.
J Natl Cancer Inst, 44 (1970), pp. 263-274
[10.]
J.D. Boice Jr., J.F. Fraumeni Jr..
Second cancer following cancer of the respiratory system in Connecticut, 1935-1982.
Natl Cancer Inst Monogr, 68 (1985), pp. 83-98
[11.]
M. Brown.
Second primaries in cases of the larynx.
J Laryngol Otol, 92 (1978), pp. 991-996
[12.]
P. Dartevelle, J. Khalife.
Surgical approach to local recurrence and the second primary lesion.
Lung Cancer. International Trends in General Thoracic Surgery., WB Saunders Company, (1985), pp. 156-163
[13.]
E. Deviri, A. Bartal, M. Goldsher, I. Eliachar, R. Steinitz, E. Robinson.
Ocurrence of additional primary neoplasms in patients with laryngeal carcinoma in Israel (1960-1976).
Ann Otol Rhinol Laryngol, 91 (1982), pp. 261-265
[14.]
J.L. Gluckman, J.D. Crissman.
Survival rates in 548 patients with multiple neoplasms of the upper aero-digestive tract.
Laryngoscope, 93 (1983), pp. 71-74
[15.]
G.J. Hordijk, J.M.A. Delong.
Syncronous and metachronous tumours in patients with head and neck cancer.
J Laryngol Otol, 97 (1983), pp. 619-621
[16.]
J. Lundgren, J. Olofsson.
Multiple primary malignancies in patients treated for laryngeal carcinoma.
J Otolaryngol, 15 (1986), pp. 145-150
[17.]
H. Miyahara, K. Yoshino, K. Umanati, et al.
Multiple primary tumours in laryngeal cancer.
J Laryngol Otol, 99 (1985), pp. 999-1004
[18.]
J.H. Olsen.
Second cancer following cancer of the respiratory System in Denmark.
Natl Cancer Ins Monogr, 68 (1985), pp. 309-312
[19.]
N. De Vries, G.B. Snow.
Multiple primary tumours in laryngeal cancer.
J Laryngol Otol, 100 (1986), pp. 915-918
[20.]
J.J. Vyas, R.K. Deshpande, S. Sharma, P.B. Desai.
Multiple primary cancers in indian population. Metachronous and synchronous lesions.
J Surg Oncol, 23 (1983), pp. 239-249
[21.]
W.K. Hong, S.M. Lippman, L.M. Itri, et al.
Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.
N Engl J Med, 323 (1990), pp. 795-801
[22.]
W.F. Judson, P.J. Harbrecht, D.E. Fry.
Associated lung lesion in patients with primary head and neck carcinoma.
Am Surg, 49 (1983), pp. 487-491
[23.]
N.P. Martini, M.R. Melamed.
Local recurrence and new pri mary carcinoma after resection.
Lung Cancer. International Trends in General Thoracic Surgery., WB Saunders Company, (1985), pp. 164-182
[24.]
B.S. Schoenberg.
Index tumors of the respiratory System multiple primary malignant neoplasms. Recent results in cancer research.
Springer Verlag, (1977),
[25.]
O. Kleinsasser.
Tumors of the larynx and hypopharynx.
Thieme Medical Publishers Inc, (1988), pp. 9-10
[26.]
N. Green, W. Kern.
The clinical course and treatment results of patients with postresection locally recurrent lung cancer.
Cancer, 42 (1978), pp. 2478-2482
[27.]
A.H. Shikhani, G.M. Matanoski, M.M. Jones, H.K. Kashima, M.E. Johns.
Multiple primary malignancies in head and neck cancer.
Arch Otolaryngol Head Neck Surg, 112 (1986), pp. 1172-1179
[28.]
S. McDonald, C. Haie, P. Rubin, D. Nelson, L.D. Divers.
Second malignant tumors in patients with laryngeal carcinoma: Diagnosis, treatment and prevention.
Int J Radiation Oncology Biol Phys, 17 (1989), pp. 457-465
[29.]
A. Croce, M. De Vicentiis, G. Primerano, A. Moretti, E.A. Rendina.
Association of primary malignant neoplasms of the larynx and the lung. 12 years of clinical experience.
Acta Otorhinolaryngol Ital, 10 (1990), pp. 19-25
[30.]
C.J. Hoekstra, P.C. Levendag, W.L. Van Putten.
Squamous carcinoma of the supraglottic larynx without clinically detectable lymph node metastases: problem of local relapse influence of overall treatment time.
Int J Radiation Oncol Biol Phys, 18 (1990), pp. 13-21
[31.]
P. Rubin, S. McDonald, C. Haie, L. Divers.
The increased incidence of second malignant tumors (SMT) following treatment for early larynx cancer (meeting abstract).
Proc Ann Meet Am Soc Clin Oncol, 8 (1989), pp. A370
[32.]
W.K. Hong, R.H. Bromer, D.A. Amato, et al.
Patterns of relapse in locally advanced head and neck cancer patients who achieved complete remission after combined modality therapy.
Cancer, 56 (1985), pp. 1242-1245
[33.]
A.M. Cohn, S.B. Peppard.
Multiple primary malignant tumors of the head and neck.
Am J Otolaryngol, 1 (1980), pp. 411-417
[34.]
L.V. Johansen, J. Overgaard, M. Hjelm-Hansen, C.C. Gadeberg.
Primary radiotherapy of T1 squamous cell carcinoma of the larynx: analysis of 478 patients treated from 1963 to 1985.
Int J Radiation Oncology Biol Phys, 18 (1990), pp. 1307-1313
[35.]
S. Silverman Jr., M. Gorsky, D. Greenspan.
Tobacco usage in patients with head and neck carcinomas: a follow-up study on habit changes and second primary oral/oropharyngeal cancers.
J Am Dent Assoc, 106 (1983), pp. 33-35
[36.]
G.W. McGarry, E.K. Mackenzie.
Second primary tumours of the larynx following bronchial carcinoma.
J Laryngol Otol, 104 (1990), pp. 629-630
[37.]
V.L. Ernster.
Trends in smoking, cancer risk, and cigarette promotion. Current priorities for reducing tobacco exposure.
Cancer, 62 (1988), pp. 1702-1712
[38.]
E.E. Floyd, A.M. Jetten.
Retinoids, growth factors and tracheobronchial epitelium.
Lab Invest, 59 (1988), pp. 1-4
[39.]
W.K. Hong, J. Endicott, L.M. Itri, et al.
13-cis-retinoic acid in the treatment of oral leukoplakia.
N Engl J Med, 315 (1986), pp. 1501-1505
[40.]
K.H. Kraemer, J.J. Digiovanna, A.N. Moshell, R.E. Tarone, G.L. Peck.
Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin.
N Engl J Med, 318 (1988), pp. 1633-1637
[41.]
S.M. Lippman, J.F. Kessler, F.L. Meyskens.
Retinoids as preventive and therapeutic anticancer agents.
Cancer Treat Rep, 71 (1987), pp. 391-405
[42.]
S.M. Lippman, J.F. Kessler, F.L. Meyskens.
Retinoids as preventive and therapeutic anticancer agents.
Cancer Treat Rep, 71 (1987), pp. 493-515
[43.]
S.M. Lippman, F.L. Meyskens.
Treatment of advanced squamous cell carcinoma of the skin with isotretinoin.
Ann Intern Med, 107 (1987), pp. 499-501
[44.]
S.M. Lippman, J.F. Kessler, M. Al-Sarraf, et al.
Treatment of advanced squamous cell carcinoma of the head and neck with isotretinoin: a phase II randomized trial.
Invest New Drugs, 6 (1988), pp. 51-56
[45.]
R. Lotan, P.G. Sacks, D. Lotan, W.K. Hong.
Differential effects retinoic acid on the in vitro growth and cell surface glycoconjugates of two human head and neck squamous cell carcinomas.
Int J Cancer, 40 (1987), pp. 224-229
[46.]
J.S. Bertram, L.N. Kolonel, F.L. Meyskens Jr..
Rational and strategies for chemoprevention of cancer in humans.
Cancer Res, 47 (1987), pp. 3012-3031
[47.]
R.M. Evans.
The steroid and thyroid hormone receptor superfamily.
Science, 240 (1988), pp. 889-895
[48.]
S.M. Lippman, B.B. Toth, J.G. Batsakis, et al.
Low-dose 13-cisretinoic acid (13cRA) maintains remission in oral premalignancy: more effective than beta-carotene in randomized trial (Abstrae).
Proc Am Soc Clin Oncol, 9 (1990), pp. 59
[49.]
C.W. Boone, G.J. Kellof, W.E. Malone.
Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.
Cancer Res, 50 (1990), pp. 2-9
[50.]
D. Trickler, G. Schklar.
Prevention by vitamin E of experimental oral carcinogenesis.
J Natl Cancer Inst, 78 (1987), pp. 165-169
[51.]
H.F. Stich, M.P. Rosin, A.P. Hornby, et al.
Remission of oral leukoplakias and micronuclei in tobbaco/betel quid chewers treated with betacarotene and with beta-carotene plus vitamin A.
Int J Cancer, 42 (1988), pp. 195-199
[52.]
D. Suda, J. Schwartz, G. Shklar.
Inhibition of experimental oral carcinogenesis by topical beta carotene.
Carcinogenesis, 7 (1986), pp. 711-715
[53.]
H.F. Stich.
Micronucleated exfoliated cells as indicators for genotoxic damage and as markers in chemoprevention trials.
Nutrit Growth Cancer, 4 (1987), pp. 9-18
[54.]
R. Rostoski, M. Saupe, S. Schmorl.
Die Bergknkheit der Erzberggglente in Schneeberg in Sachsen. («Schneeberger Lungenkrebs»).
Ztschr Krebsforsch, 23 (1926), pp. 360-384
[55.]
R.F. Muller.
Uber multiple, nichtsystematisierte Primarkarcinome und ihre Haufigkeit.
Ztschr Krebsforsch, 31 (1930), pp. 339-360
[56.]
A. Pirchan, H. Sikl.
Cancer of the lung in the miners of Jachymov (Joachimstal): Report of cases observed in 1929-1930.
Am J Cancer, 16 (1932), pp. 681-722
[57.]
K. Lindberg.
Uber die Histologie des primaren Lungenkrebs.
Arb Path Inst Univ Helsingfors, 8 (1935), pp. 225-473
[58.]
E.J. Mc Grath, E.A. Gall, D.P. Kessler.
Bronchogenic carcinoma: Product of multiple sites of origin.
J Thorac Surg, 24 (1952), pp. 271-283
[59.]
M.J. Williams.
Extensive carcinoma in situ in the bronchial mucosa associated with two invasive bronchogenic carcinoma: Report of a case.
Cancer, 5 (1952), pp. 740-747
[60.]
M. Chauvet, R. Feuardent.
Cancer bronchique bilateral.
J Franç Med et Chir Torac, 8 (1954), pp. 377-380
[61.]
G. Kaihberger.
Über einen Fall von doppeltem primarem Bronchuskarzinom.
Klin Med, 10 (1955), pp. 354-360
[62.]
S.A. Howard, M.J. Wiliams.
Bilateral simultaneous ocurrence of primary squamous cell carcinoma of the lung.
Cancer, 10 (1957), pp. 1.182-1.186
[63.]
F.V. Stewarts.
Factors in influencing the curability of cancer. Third National Cancer Conference Proceedings.
JB Lippincott Co, (1957), pp. 65
[64.]
K.L. Gurkan.
Bilateral bronchogenic carcinoma: Report of a case.
I Internat Coll Surgeos, 29 (1958), pp. 763-765
[65.]
W. Newman, P.C. Adkins.
Three prymary carcinomas of the lung advising in a left lower lobe with metastases of two of the tumors.
J Thoracic Surg, 35 (1958), pp. 474-482
[66.]
C.L. Robinson, C.A. Jackson.
Multiple cancer of the lung.
J Thoracic Surg, 36 (1958), pp. 166-173
[67.]
W. Mandel, G.H. Thomas.
Simultaneous occurrence of squamous and adenocarcinoma of the lung.
California Med, 91 (1959), pp. 358-360
[68.]
Y. Le Gal, W.C. Baver.
Second primary bronchogenic carcinoma: A complication of successful lung cancer surgery.
J Thorac Surg, 41 (1961), pp. 114-124
[69.]
H.T. Langston, J.C. Sherrick.
Bilateral simultaneous bronchogenic carcinoma. Report of a case of surgical excision.
J Thorac Cardiovasc Surg, 43 (1962), pp. 742-751
Copyright © 1992. Sociedad Española de Neumología y Cirugía Torácica
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