Archivos de Bronconeumología (English Edition) Archivos de Bronconeumología (English Edition)
Arch Bronconeumol 2017;53:34 - Vol. 53 Num.1 DOI: 10.1016/j.arbr.2016.11.016
Scientific Letter
Ocular Hypertension Requiring Suspension of Inhaled Corticosteroids
Hipertensión ocular que obliga a suspender el tratamiento con corticoides inhalados
Suliana Mogrovejo, Eva Martínez Moragón, , María Climent
Servicio de Neumología, Hospital Universitario Doctor Peset, Valencia, Spain

We report the case of a 68-year-old woman who was referred to the respiratory medicine department due to a year-long history of recurrent episodes of dyspnea and wheezing. Spirometry showed a normal ventilatory pattern, with a positive bronchodilator test. A diagnosis of mild persistent asthma was made and inhaled mometasone administered using a Twishaler® device was prescribed at a dose of 400μg/day; under this treatment, the patient's exacerbations resolved and control was maintained.

The patient had also been in ophthalmologic follow-up for 7 years, due to ocular hypertension. Her intraocular pressure (IOP) by tonometry was 21.19mmHg, she was receiving latanoprost and had maintained a stable IOP for the last 4 years. After starting treatment with inhaled mometasone, a progressive increase in IOP was observed during her regular ophthalmologic check-ups, so her treatment was switched to bimatoprost. The patient did not respond, and her IOP rose to 28mmHg (right eye) and 32mmHg (left eye). Withdrawal of the inhaled corticosteroid was proposed, and 4 weeks after suspending mometasone, IOP was 17mmHg in both eyes, so the recommendation was made to definitively discontinue the treatment.

This led to a worsening of the asthma, and given the impossibility of introducing continuous inhaled corticosteroids (ICS), maintenance therapy with oral montelukast was initiated, and an inhaler with low-dose budesonide-formoterol was prescribed for use as needed. Under this treatment, IOP remained unchanged and the asthma was controlled.

ICS are the first line of treatment for asthma, although they are not free of adverse effects, particularly when treatment is prolonged and doses are high. A possible association between the use of ICS and the development of intraocular hypertension has been described. The effect of ICS on the eye is probably due not only to systemic absorption but also to the formation of topical ocular deposits as a result of nebulized administration. Ocular hypertension may be related with histological changes caused by ICS in the trabecular cells, consisting of the formation of deposits in the extracellular matrix and increased resistance to the outflow of aqueous humor.1 A genetic susceptibility to developing corticosteroid-induced glaucoma has been suggested.

Studies analyzing the relationship of ICS with glaucoma are inconclusive. Garbe et al. in a case-control study (9793 cases and 38,325 controls) found a greater risk of glaucoma among patients who used high-dose ICS (budesonide >1600μg/day) for longer than 3 months (OR: 1.44; 95% CI: 1.01–2.06). However, this study is limited by its design and the non-standardized diagnosis of glaucoma.1 Mitchell et al. performed a cross-sectional study in 3654 patients with ICS aged 49–97 years: 108 had open-angle glaucoma and 160 had intraocular hypertension. A strong association between the use of ICS and ocular hypertension was observed in individuals with a family history of glaucoma (OR: 6.3; 95% CI: 1.0–38.6), but no association was found in subjects without a family history.2 González et al., in a study of 2291 cases and 13,445 controls with a mean age of 75 years, found an RR for glaucoma after high-dose ICS at 3, 6 and 12 months of 1.01 (95% CI: 0.70–1.44), 0.92 (95% CI: 0.61–1.38) and 0.84 (95% CI: 0.70–1.44), respectively.3 In 2 prospective, randomized, double-blind, placebo-controlled clinical trials, one in 1250 patients treated with high-dose budesonide for 20 weeks,4 and the other in 22 patients treated with inhaled fluticasone for 6 weeks,5 no differences were found in IOP compared to the placebo group.

We can conclude that the relationship between the use of ICS and increased IOP or the development of glaucoma has not been completely clarified. However, these drugs should be prescribed with caution, particularly in patients with risk factors or previous glaucoma in whom IOP monitoring may be advisable during treatment. In our patient, ICS treatment worsened her glaucoma to the extent that it had to be withdrawn.

References
1
E. Garbe,J.F. Boivin,J. LeLorier,S. Suissa
Selection of controls in database case-control studies: glucocorticoids and the risk of glaucoma
J Clin Epidemiol, 51 (1998), pp. 129-135
2
P. Mitchell,R.G. Cumming,D.A. Mackey
Inhaled corticosteroids, family history, and risk of glaucoma
Ophthalmology, 106 (1999), pp. 2301-2306 http://dx.doi.org/10.1016/S0161-6420(99)90530-4
3
A.V. Gonzalez,G. Li,S. Suissa,O. Ernst
Risk of glaucoma in elderly patients treated with inhaled corticosteroids for chronic airflow obstruction
Pulm Pharmacol Ther, 23 (2010), pp. 65 http://dx.doi.org/10.1016/j.pupt.2009.10.014
4
M.S. Duh,A.M. Walker,B. Lindmark,A.M. Laties
Association between intraocular pressure and budesonide inhalation therapy in asthmatic patients
Ann Allergy Asthma Immunol, 85 (2000), pp. 356-361 http://dx.doi.org/10.1016/S1081-1206(10)62545-8
5
E.B. Moss,Y.M. Buys,S.A. Low,D. Yuen,Y.P. Jin,K.R. Chapman
A randomized controlled trial to determine the effect of inhaled corticosteroid on intraocular pressure in open-angle glaucoma and ocular hypertension: the ICOUGH Study
J Glaucoma, (2016),
[Epub ahead of print]

Please cite this article as: Mogrovejo S, Martínez Moragón E, Climent M. Hipertensión ocular que obliga a suspender el tratamiento con corticoides inhalados. Arch Bronconeumol. 2017;53:34.

Corresponding author.
Copyright © 2016. SEPAR
Arch Bronconeumol 2017;53:34 - Vol. 53 Num.1 DOI: 10.1016/j.arbr.2016.11.016