TY - JOUR T1 - Lung Transplantation in Cystic Fibrosis and the Impact of Extracorporeal Circulation JO - Archivos de Bronconeumología T2 - AU - Jauregui,Alberto AU - Deu,Maria AU - Romero,Laura AU - Roman,Antonio AU - Moreno,Antonio AU - Armengol,Manuel AU - Solé,Juan SN - 15792129 M3 - 10.1016/j.arbr.2018.04.007 DO - 10.1016/j.arbr.2018.04.007 UR - https://archbronconeumol.org/en-lung-transplantation-in-cystic-fibrosis-articulo-S1579212918301368 AB - IntroductionLung disease is the major cause of death among cystic fibrosis (CF) patients, affecting 80% of the population. The impact of extracorporeal circulation (ECC) during transplantation has not been fully clarified. This study aimed to evaluate the outcomes of lung transplantation for CF in a single center, and to assess the impact of ECC on survival. MethodsWe performed a retrospective observational study of all transplanted CF patients in a single center between 1992 and 2011. During this period, 64 lung transplantations for CF were performed. ResultsFive- and 10-year survival of transplanted patients was 56.7% and 41.3%, respectively. Pre-transplantation supplemental oxygen requirements and non-invasive mechanical ventilation (NIMV) do not seem to affect survival (P=.44 and P=.63, respectively). Five- and 10-year survival among patients who did not undergo ECC during transplantation was 75.69% and 49.06%, respectively, while in those did undergo ECC during the procedure, 5- and 10-year survival was 34.14% and 29.87%, respectively (P=.001). PaCO2 is an independent risk factor for the need for ECC. ConclusionsThe survival rates of CF patients undergoing lung transplantation in our hospital are similar to those described in international registries. Survival is lower among patients receiving ECC during the procedure. PaCO2 is a risk factor for the need for ECC during lung transplantation. ER -