Association Between the Forced Midexpiratory Flow/Forced Vital Capacity Ratio and Bronchial Hyperresponsiveness

Urrutia, I.; Capelastegui, A.; Quintana, J.M.; Muniozguren, N.; Payo, F.; Martínez Moratalla, J.; Maldonado, J.A.; Basagana, X.; Anto, J.M.; Sunyer, J.

doi:10.1016/S1579-2129(06)60342-X

Archivos de Bronconeumología

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Vol. 40. Issue 9.

Pages 397-402 (September 2004)

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Pages 397-402 (September 2004)

Original Articles

DOI: 10.1016/S1579-2129(06)60342-X

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Association Between the Forced Midexpiratory Flow/Forced Vital Capacity Ratio and Bronchial Hyperresponsiveness

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I. Urrutiaa,

Corresponding author

isabhelurrutia@airtel.net

Correspondence: Dra. I. Urrutia. Servicio de Neumología. Hospital de Galdakao. B.° Labeaga, s/n. 48960 Galdakao. Vizcaya. España

, A. Capelasteguia, J.M. Quintanab, N. Muniozgurenc, F. Payod, J. Martínez Moratallae, J.A. Maldonadof, X. Basaganag, J.M. Antoh, J. Sunyerh, the Spanish Group of the European Community Respiratory Health Survey (ECRHS-I) *

a Servicio de Neumología, Hospital de Galdakao, Galdakao, Vizcaya, Spain

b Unidad de Epidemiología de Investigación Clínica, Hospital de Galdakao, Galdakao, Vizcaya, Spain

c Departamento de Sanidad del Gobierno Vasco, Bilbao, Spain

d Hospital de Asturias, Oviedo, Spain

e Complejo Universitario, Albacete, Spain

f Hospital Juan Ramón Jiménez, Huelva, Spain

g Unidad de Investigación Respiratoria y Ambiental, Instituto Municipal de Investigación MeAdica, Barcelona, Spain

h Unidad de Investigación Respiratoria y Ambiental, Instituto Municipal de Investigación Médica, Departamento de Ciencias Experimentales y de la Salud, Universidad Pompeu Fabra, Barcelona, Spain

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Abstract

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Objective

A long-standing hypothesis is that a low ratio of airway caliber to lung size is associated with bronchial hyperresponsiveness (BHR). The aim of our study was to measure the association between airway caliber relative to lung size (expressed as the ratio between forced expiratory flow, midexpiratory phase, divided by forced vital capacity [FEF25%-75%/FVC]) and BHR measured by a methacholine challenge test, adjusting for age, height, sex, smoking history, geographic area, respiratory symptoms, and baseline forced expiratory volume in 1 second (FEV1).

Material and methods

We carried out a multicenter cross-sectional study of the general Spanish population in 2647 subjects from the European Community Respiratory Health Survey (ECRHS I). The ECRHS questionnaire was administered, total and specific immunoglobulin E were measured, and skin tests, spirometry, and a methacholine challenge test were performed.

Results

We show the relationship of the various clinical and sociodemographic variables with the 2 parameters indicative of a positive methacholine test. The lower the FEF25%-75%/FVC ratio was, the greater the risk of HRB, after adjustment for variables (odds ratio [OR]=0.09; 95% confidence interval [CI], 0.04-0.018 for the concentration provoking a 20% decrease in FEV1, and OR=0.06; 95% CI, 0.03-0.12 for the dose provoking a 20% decrease in FEV1).

Conclusions

There is a significant association between the FEF25%-75%/FVC ratio and BHR after adjustment for age, atopy, smoking, geographic area, respiratory symptoms, and initial FEV1.

Key Words:

Bronchial hyperresponsiveness

Lung size

FEF25%-75%/FVC.

Objetivo

La desproporción entre el calibre de la vía aeArea y el pareAnquima pulmonar tiene una relación negativa con la presencia de hiperreactividad bronquial (HRB).

El objetivo del presente estudio es medir la asociación entre el calibre de la vía aeArea relativa a la talla pulmonar, expresado por el cociente entre el flujo mesoespiratorio entre el 25 y el 75% de la capacidad vital forzada dividido por la capacidad vital forzada (FEF25-75%/FVC), con la HRB medida por el test de metacolina, ajustando por edad, altura, sexo, consumo de tabaco, área geográfica, síntomas respiratorios y volumen espiratorio forzado en el primer segundo previo.

Material y Métodos

Estudio multiceAntrico transversal sobre población general española (2.647 sujetos) del Estudio de Salud Respiratoria de la Comunidad Europea (ECRHS-I). Se aplicó un cuestionario llamado ECRHS, se determinó la inmunoglobulina E total y específica, y se realizaron pruebas cutáneas, espirometría y test de metacolina.

Resultados

Se presenta la relación entre las diferentes variables sociodemográficas y clínicas con los 2 parámetros de positividad del test de metacolina. Hay aumento del ries-go de HRB a menor cociente FEF25 75%/FVC ajustado por diferentes variables (odds ratio = 0,09; intervalo de confianza del 95%, 0,04-0,18, para PC20, y odds ratio = 0,06; intervalo de confianza del 95%, 0,03-0,12 para PD20).

Conclusiones

El cociente FEF25-75%/FVC está asociado significativamente a la HRB, independientemente de la edad, la existencia de atopia, el consumo de tabaco, el área geográfica, los síntomas respiratorios y el volumen espiratorio forzado en el primer segundo.

Palabras clave:

Hiperreactividad bronquial

Talla pulmonar

FEF25-75%/FVC.

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REFERENCES

[1]

PJ Barnes, ST Holgate.

Pathogenesis and hyperreactivity.

Respiratory medicine, pp. 558-603

[2]

NGM Orie, HJ Switer, K de Uries, GJ Tammeling, J Witkop.

The host factor in bronchitis.

Bronchitis, pp. 43-59

[3]

GT O'Connor, D Sparrow, ST Weiss.

The role of allergy and nonspecific airway hyperresponsiveness in the pathogenesis of chronic obstructive pulmonary disease.

Am Rev Respir Dis, 140 (1989), pp. 225-252

[4]

VJ Carey, ST Weiss, IB Tager, SR Leader, FE Speizer.

Airway responsiveness, wheeze onset, and recurrent asthma episodes in young adolescents.

Am J Respir Crit Care Med, 153 (1996), pp. 356-361

http://dx.doi.org/10.1164/ajrccm.153.1.8542143 | Medline

[5]

D Sparrow, GT O'Connor, RC Basner, B Rosner, ST Weiss.

Predictors of the new onset of wheezing among middle-aged and older men.

Am Rev Respir Dis, 147 (1993), pp. 367-371

http://dx.doi.org/10.1164/ajrccm/147.2.367 | Medline

[6]

JB Soriano, A Tobías, M Kogevinas, J Sunyer, M Sáez, J Martínez Moratalla, the Spanish Group of the European Community Respiratory Health Survey Atopy and Non-specific Bronchial Responsiveness.

A population-based assessment.

Am J Respir Crit Care Med, 154 (1996), pp. 1636-1640

[7]

D Gurwitz, C Murdorff, H Levison.

Increased incidence of bronchial reactivity in children with a history of bronchiolitis.

J Pediatr, 98 (1981), pp. 551-555

Medline

[8]

GB Mallory, H Chaney, RL Mutrich, EK Motoyama.

Longitudinal changes in lung function during the first three years of premature infants with moderate to severe bronchopulmonary dysplasia.

Pediatr Pulmonol, 11 (1991), pp. 8-14

Medline

[9]

M Chang-Yeung, S Vedal, J Kus, L MacLean, D Enarson, KS Ise.

Symptoms, pulmonary function, and bronchial hyperreactivity in western red cedar workers compared with those in office workers.

Am Rev Respir Dis, 130 (1984), pp. 1038-1041

[10]

T Weiss Scott, IB Tager, W Weiss, A Muñoz, FE Speizer, R Ingram.

Airway responsiveness in a population sample of adults and children.

Am Rev Respir Dis, 129 (1984), pp. 898-902

http://dx.doi.org/10.1164/arrd.1984.129.6.898 | Medline

[11]

J Sunyer, JM Antó, M Kogevinas, JB Soriano, A Tobías, A Muñoz, the Spanish Group of the European Study of Asthma.

Smoking and bronchial responsiveness in nonatopic and atopic young adults.

Thorax, 52 (1997), pp. 235-238

Medline

[12]

JK Peat, CM Salome, W Xuan.

On adjusting measurements of airway responsiveness for lung size and airway calibre.

Am J Respir Crit Care Med, 154 (1996), pp. 870-875

http://dx.doi.org/10.1164/ajrccm.154.4.8887577 | Medline

[13]

AA Litonjua, D Sparrow, ST Weiss.

The FEF25-75/FVC is associated with methacholine airway responsiveness. The Normative Aging Study.

Am J Respir Crit Care Med, 159 (1999), pp. 1574-1579

[14]

PGJ Burney, C Luczynska, S Chinn, D Jarvis.

The European Community Respiratory Health Survey.

Eur Respir J, 7 (1994), pp. 954-960

Medline

[15]

Grupo Español del Estudio Europeo del Asma.

Estudio Europeo del Asma. Prevalencia de hiperreactividad bronquial y asma en adultos jóvenes de cinco Áreas españolas.

Med Clin (Barc), 106 (1996), pp. 761-767

[16]

PGJ Burney, S Chinn.

Developing a new questionnaire for measuring the prevalence and distribution of asthma.

Chest, 91 (1987), pp. 795-835

[17]

PhH Quanjer, GJ Tammeliny, JE Cotes, R Pedersen, R Peslin, JC Yernault.

Lung volumes and forced ventilatory flows: report of working party, standardisation of lung function test. Community for steel and coal official statement of the European Respiratory Society.

Eur Respir J, 6 (1993), pp. 5-40

Medline

[18]

American Thoracic Society.

Lung function testing: selection of reference values and interpretative strategies.

Am Rev Respir Dis, 144 (1991), pp. 1202-1218

http://dx.doi.org/10.1164/ajrccm/144.5.1202 | Medline

[19]

PJ Sterk, LM Fabbri, PhH Quanjer, DW Cockcroft, PM O'Byrne, SD Anderson, et al.

Airway responsiveness. Standardized challenge testing with pharmacological physical and sensitising stimuli in adults.

Eur Respir J, 6 (1993), pp. 53-83

Medline

[20]

J Sunyer, A Muñoz, the Spanish Group of the European Asthma study.

Concentrations of methacholine for bronchial responsiveness according to symptoms, smoking and immunoglobulin E.

Am J Respir Crit Care Med, 153 (1996), pp. 1273-1279

http://dx.doi.org/10.1164/ajrccm.153.4.8616553 | Medline

[21]

J Mead.

Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil and vital capacity.

Am Rev Respir Dis, 121 (1980), pp. 339-342

http://dx.doi.org/10.1164/arrd.1980.121.2.339 | Medline

[22]

IB Tager, ST Weis, A Muñoz, C Welty, FE Speizer.

Determinants of response to eucapnic hyperventilation with cold air in a population-based study.

Am Rev Respir Dis, 134 (1986), pp. 502-508

http://dx.doi.org/10.1164/arrd.1986.134.3.502 | Medline

[23]

GG Collis, H Cole, PN Le Soüef.

Dilution of nebulised aerosols by air entrainment in children.

Lancet, 336 (1990), pp. 341-343

Medline

[24]

JK Peat, EJ Gray, CM Mellis, SR Leader, AJ Woolcock.

Differences in airway responsiveness between children and adults living in the same environment: an epidemiological study in two regions of New South Wales.

Eur Respir J, 7 (1994), pp. 1805-1813

Medline

The ECRHS has received support from the European Economic Community and grants FIS 91/00160600E-OSE and 93/0393.

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