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Vol. 31. Issue 2.
Pages 83-85 (February 1995)
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Vol. 31. Issue 2.
Pages 83-85 (February 1995)
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Alternativa terapéutica para los aspergilomas pulmonares complicados no quirúrgicos
Therapeutic alternatives for non-operable, complicated pulmonary aspergilloma
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J. Ortiz de Saracho1, E. Pérez-Rodríguez, P. Navío, J. Flores
Servicios de Neumología, Hospital Ramón y Cajal. Madrid
J. Zapatero*, J. Sánchez**
* Servicios de Cirugía Torácica, Hospital Ramón y Cajal. Madrid
** Servicios de Radiodiagnóstico. Hospital Ramón y Cajal. Madrid
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Se presentan 2 casos de aspergiloma pulmonar (AP) complicado por hemoptisis masiva y criterios de inoperabilidad, en los que, tras fracasar la embolización arterial, se realizó un protocolo terapéutico con anfotericina B a través de un catéter intracavitario. A pesar del tamaño de los micetomas la respuesta terapéutica fue excelente con regresión completa del aspergiloma a las 3-4 semanas de tratamiento, negativizándose las precipitinas frente Aspergillus fumigatus y la presencia del hongo en las muestras del aspirado transcatéter. La hemoptisis masiva fue controlada con ácido épsilon-aminocaproico instilado a través del catéter. No hubo complicaciones, el tratamiento fue bien tolerado y no se observaron recidivas en el seguimiento a lo largo de 24 y 18 meses, respectivamente. Este tratamiento local es la mejor alternativa terapéutica para los AP complicados no operables.

Palabras clave:
Aspergiloma pulmonar
Tratamiento percutáneo
Anfotericina B

We present 2 patients with pulmonar) aspergilloma complicated by massive hemoptysis who were not good candidates for surgery and were treated with intracavitary amphotericin B after arterial embolization failed. In spite of the size of the mycetomas, response to treatment was excellent with full regression of the aspergilloma after 3 to 4 weeks; precipitins to Aspergillus fumigatus became negative and the fungus disappeared from transcatheter aspirate samples. Massive hemoptysis was controlled with epsilon-amino-caproic acid instilled by catheter. No complications were observed, the treatment was well tolerated and no recurrence occurred over a follow-up period of 24 and 18 months, respectively. This local treatment is the best therapeutic alternative for patients with pulmonary aspergilloma who are not candidates for surgery.

Key words:
Pulmonary aspergilloma
Percutaneous treatment
Amphotericin B
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Bibliografía
[1.]
R.A. Glimp, A.S. Bayer.
Pulmonary aspergilloma: diagnostic and therapeutic considerations.
Arch Intern Med, 143 (1983), pp. 303-306
[2.]
H.L. Israel, G.S. Lenchner, G.W. Atkinson.
Sareoidosis and aspergilloma: the role fo surgery.
Chest, 32 (1982), pp. 430-432
[3.]
J.R. Tomlinson, S.A. Shan.
Arpergilloma in sarcoid and tuberculosis.
Chest, 92 (1987), pp. 505-508
[4.]
T. Hamamoto, K. Watanabe, H. Ikemoto.
Endobronchial miconazole for pulmonary aspergilloma.
Ann Intern Med, 98 (1983), pp. 1.030
[5.]
R.J. Ramírez.
Pulmonary aspergilloma: endobronchial treatment.
N Engl J Med, 271 (1964), pp. 1.281-1.285
[6.]
H.T. Adelson, J.A. Malcom.
Endocavitary treatment of pulmonary mycetomas.
Am Rev Respir Dis, 98 (1968), pp. 87-92
[7.]
J.L. Hargis, C.L. Bone, J. Stewart, N. Rector, F.C. Hiller.
Intracavitary amphotericin B in the treatment of symptomatic pulmonary aspergillomas.
Am J Med, 68 (1980), pp. 389-394
[8.]
M.J. Saphiro, S.M. Albelda, R.L. Mayock, G.K. McLean.
Severe hemoptysis associated with pulmonary aspergilloma. Percutaneous intracavitary treatment.
Chest, 94 (1988), pp. 1.225-1.231
[9.]
K.S. Lee, Y.H. Kim, W.K. Bae.
Percutaneous intracavitary treatment of a giant aspergilloma.
[10.]
K.J. Hammerman, C.S. Christianson, I. Huntington, G.A. Hurst, M. Zelman, F.E. Tosh.
Spontaneous lysis of aspergillomata.
Chest, 64 (1973), pp. 697-699
[11.]
W.E. Dismukes.
Azole antifung al drugs: old a new.
Ann Intern Med, 109 (1988), pp. 177-179
[12.]
P. Phillips, R. Fetchick, I. Weisman, S. Foshee, J.R. Graybill.
Tolerance to and efficacy of itraconazole in treatment of systemic mycoses: preliminary results.
Rev Infect Dis, 9 (1987), pp. 87-93
[13.]
B. Dupont, E. Drouhet.
Early experience with itraconazole in vitro and in patients: pharmacokinetic studies and clinical results.
Rev Infect Dis, 9 (1987), pp. 71-76
[14.]
J.H. Campbell, J.H. Winter, M.D. Richardson, G.S. Shankland, S.W. Banham.
Treatment of pulmonary aspergilloma with itraconazole.
Thorax, 46 (1991), pp. 839-841
[15.]
H. Yamada, S. Kohno, H. Koga, S. Maesaki, M. Kaku.
Topical treatment of pulmonary Aspergilloma by antifungals. Relationship Between Duration of the Disease and Efficacy of Therapy.
Chest, 103 (1993), pp. 1.421-1.425
[16.]
P.L. Munk, A.D. Vellet, R.N. Rankin, N.L. Müller, D. Ahmad.
Intracavitary Aspergilloma: Transthoracic Percutaneous Injection of Amphotericin Gelatin Solution.
Radiology, 188 (1993), pp. 821-823
[17.]
J.M. Giron, C.G. Poey, P.P. Fajadet, G.B. Balagner, J.P. Assoun, G.R. Richardi, et al.
Inoperable Pulmonary Aspergilloma: Percutaneous CT-guided Injection with Glycerin and Amphotericin B Paste in 15 cases.
Radiology, 188 (1993), pp. 825-827
Copyright © 1995. Sociedad Española de Neumología y Cirugía Torácica
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