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Vol. 42. Issue 3.
Pages 151-153 (March 2006)
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Vol. 42. Issue 3.
Pages 151-153 (March 2006)
Case Reports
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A Lung Transplant in a Woman With Bronchiolitis Obliterans Following an Allogenic Bone Marrow Transplant
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J. Redel-Monteroa,
Corresponding author
javierredel@msn.com

Correspondence: Dr. J. Redel-Montero. Avda. Arruzafilla, 7, portal 4, 2.° I. 14011 Córdoba. España
, F. Santos-Lunaa, R. Lama-Martíneza, J. Algar-Algarb, A. Salvatierra-Velázquezb, A. Álvarez-Kindelánb
a Unidad de Trasplante Pulmonar, Servicio de Neumología, Hospital Universitario Reina Sofía, Córdoba, Spain
b Unidad de Trasplante Pulmonar, Servicio de Cirugía Torácica, Hospital Universitario Reina Sofía, Córdoba, Spain
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Graft-versus-host disease is a major complication for bone marrow transplant recipients and is often a cause of late mortality. It can affect any tissue, and involvement of the lungs—target organs of particular importance—can lead to chronic respiratory failure due to bronchiolitis obliterans.

We report the case of a lung transplant in a woman who developed bronchiolitis obliterans after receiving a marrow transplant to treat bone marrow aplasia. Three years later, clinical course was satisfactory, with full functional recovery.

Key words:
Bone marrow aplasia
Bone marrow transplantation
Bronchiolitis obliterans
Lung transplant

La enfermedad del injerto contra el huésped es una com-plicación importante de los pacientes sometidos a trasplante de médula ósea, en quienes es causa de una elevada mortali-dad tardía. Puede afectar a cualquier tejido y, cuando afecta a los pulmones, que son órganos diana de particular rele-vancia, acarrea insuficiencia respiratoria crónica secunda-ria al desarrollo de bronquiolitis obliterante.

Presentamos el caso de una paciente con trasplante pulmonar por bronquiolitis obliterante tras haber recibido un trasplante de médula ósea por aplasia medular. La evolución tras el trasplante pulmonar, a los 3 años de seguimiento, es favorable, con recuperación clínica y funcional completa.

Palabras clave:
Aplasia medular
Trasplante de médula ósea
Bronquiolitis obliterante
Trasplante pulmonar
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REFERENCES
[1]
JO Armitage.
Bone marrow transplantation.
N Engl J Med, 330 (1994), pp. 827-838
[2]
AP Schwarer, JMB Hughes, B Trotman-Dieckenson, T Krausz, JM Goldman.
A chronic pulmonary syndrome associated with graft-versus-host disease after allogenic marrow transplantation.
Transplantation, 54 (1992), pp. 1002-1008
[3]
SW Crawford, JG Clark.
Bronchiolitis associated with bone marrow transplantation.
Clin Chest Med, 14 (1993), pp. 741-749
[4]
F Santos Luna, R Lama Martínez.
Trasplante pulmonar. Criterios de selección y evaluación de candidatos.
Neumosur, 12 (2000), pp. 123-133
[5]
JG Clark, SW Crawford, DK Madtes, KM Sullivan.
Obstructive lung disease after allogenic marrow transplantation. Clinical presentation and course.
Ann Intern Med, 11 (1989), pp. 368-376
[6]
A Gascoigne, P Corris.
Lung transplants in patients with prior bone marrow transplantation.
Chest, 105 (1994), pp. 327
[7]
JH Calhoon, S Levine, A Anzueto, CL Bryan, JK Trinkle.
Lung transplantation in a patient with a prior bone marrow transplant.
Chest, 102 (1992), pp. 948
[8]
UG Svendson, S Aggestrup, C Heilmann.
Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow.
J Heart Lung Transplant, 18 (1999), pp. 388-390
[9]
W Rabitsch, E Deviatko, F Keil, C Herold, G Dekan, HT Greinix, et al.
Successful lung transplantation for bronchiolitis obliterans after allogenic marrow transplantation.
Transplantation, 71 (2001), pp. 1341-1343
[10]
JA Heath, G Kurland, TL Spray, NA Kernan, TN Small, JA Brochstein, et al.
Lung transplantation after allogenic marrow transplantation in pediatric patients: the Memorial Sloan-Kettering experience.
Transplantation, 72 (2001), pp. 1986-1990
[11]
AJ Norin, EM Goodell, SL Kamholz, FJ Veith, DA Blumenstock.
Immunologic, morphologic, and functional evaluation of long-term-surviving beagle lung allograft recipients treated with lethal total-body irradiation, autologous bone marrow, and methotrexate.
Transplantation, 44 (1987), pp. 179-184
Copyright © 2006. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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